taking pristiq with nset pain relievers, aspirin, or blood thinners may increase bleeding risk. tell your doctor about all your medications, including those for migraine, to avoid a potentially life threatening condition. pristiq may cause or worsen high blood pressure, high cholesterol, or glaucoma. tell your doctor if you have heart disease, or before you reduce or stop taking pristiq. side-effects may include nausea, dizziness and sweating. for me, pristiq is a key in helping me treat my depression. side-effects may include nausea, dizziness and sweating. the mississippi river has risen more than 5 feet in the past few days. and has taken over part of downtown st. paul.